Constance Therapeutics Archives - Green Market Report

Debra BorchardtMay 9, 2018


Here’s is your cannabis news highlights for May 9, 2018:

On The Site

The Green Organic Dutchman Holdings Ltd.

The Green Organic Dutchman  (TSX:TGOD) announced that it has issued an additional 4,726,500 units at $3.65 per Over-Allotment Unit raising additional aggregate gross proceeds of $17,251,725 pursuant to the exercise of the over-allotment option. This option was which was associated with the recent IPO granted to a syndicate of agents co-led by Canaccord Genuity Corp. as sole bookrunner and PI Financial Corp., and including Industrial Alliance Securities Inc., INFOR Financial Inc., Echelon Wealth Partners Inc. and Mackie Research Capital Corporation.

With the Over-Allotment Option, TGOD will have raised aggregate gross proceeds of $132,263,225 under the IPO by issuing an aggregate of 36,236,500 units of TGOD, including the Over-Allotment Units.

Moody’s New Report

A new report from Moody’s highlights the impact that legalized marijuana could have in the U.S. and Canada and the implications for other recreational substances, such as alcohol could be damning.

Moody’s estimates that marijuana could replace alcohol “on some occasions,” but spirits makers aren’t sitting on their laurels. Beer maker Constellation Brands ( STZ) purchased a 9.9 percent stake in Canopy Growth, a Canadian cannabis company. Additionally, Scotts Miracle-Gro (SMG) and leaf tobacco company Alliance One International have both acquired or invested in cannabis-related companies.

High Yield Insights Also Reports On Alcohol

In states where legalization has occurred, recreational marijuana consumers are now using far less alcohol and over-the-counter medications, according to a new report by High Yield Insights.

The consumer behavior company looked at feedback from recreational users in states where recreational cannabis is legal. They found that more than 20 percent of people who consume marijuana recreationally are using 27 percent less OTC pain relievers and 21 percent less alcoholic beverages. Those weren’t the only steep drops found, either. The report also indicated those consumers are using 22 percent fewer sleep aids, consuming 20 percent less beer, and 18 percent less wine.

In Other News

Constance Therapeutics

Constance Therapeutics, a vertically-integrated medicinal cannabis company, announces a new partnership with Kanabo Research, an Israel-based startup that develops clinical solutions for extraction and vaporization of medical cannabis.

This collaboration will bring together Constance Therapeutics’ demonstrated a long history of developing standardized and evidence-based cannabis extracts with Kanabo’s patent-protected precision dosing hardware. Under the partnership, both companies will operate in the EU to establish a cannabis cultivation farm as well as manufacturing capabilities of cannabis active compounds – THC and CBD – to be used in an array of medical treatments of ailments such as insomnia, PTSD, and chronic pain. Simultaneously, Constance Therapeutics will market Kanabo Research’s solutions in the US market, where CT has been operating since 2008.

Endexx Corporation

Endexx Corporation (EDXC), a provider of innovative phytonutrient-based food and nutritional products, has completed its acquisition of Go Green Global Enterprises Inc. to secure an international distribution hub in Jamaica for its entire array of cannabidiol (CBD) based products to key markets, among which are Canada, Europe, South and Central America and the Caribbean. By having a company based in Jamaica, Endexx can legally export its CBD products and Innovative Autospense products internationally, possibly increasing substantially its revenue and earnings.

Endexx is pursuing multiple licenses in Jamaica to establish a vertical market to grow, process, transport, dispense, sell, and export its entire array of products, both current and future. The Company’s CBD Unlimited line of cannabidiol (CBD) Cannsummable Portfolio products includes its formulated topical CBD balm and mist, travel sleep aid, teas, oils, capsules, soft chews for dogs and cats, and other products that provide key benefits to users.

Marijuana Company of America Inc.

Marijuana Company of America (MCOA) announced that it has signed a Joint Venture Agreement with Global Hemp Group Inc. (GBHPF) to cultivate legal high yielding CBD from industrial hemp at its recently acquired 109-acre farm (see news release of May 1, 2018) in Scio, Oregon.

Pursuant to the terms of the Agreement, MCOA and GHG  will jointly invest a total of US$1.2 million in the development of the project in 2018. Funding for the project will be done on a 50/50 basis.

Isodiol International Inc. 

Isodiol International Inc.  (ISOLF) announced that it has signed a Letter of Intent (“LOI”) with Zenabis Ltd. (“Zenabis ”), one of Canada’s largest Licensed Producers, to import CBD isolate as an Active Pharmaceutical Ingredient, into Canada from Isodiol’s GMP-certified production facility in the United Kingdom.

Root Origins

Root Origins announced today the launch of its sublingual oral CBD sprays. The peppermint-flavored sprays are available in DAY and NIGHT. The products provide an effective solution for those who find themselves limiting their activities due to aches, pains, sleeplessness or anxiety. Both sprays deliver accurate 1mg doses of CBD to deliver fast-acting relief.


Debra BorchardtApril 3, 2018


She is the Founder of Constance Therapeutics. She’s also the Chief Executive Officer, the head of Research & Development and she owns all the company patents. “The work is mine,” said Constance Finley. Her company is now 10 years old, she has 11 employees and has begun globally licensing her products. There is so much demand for her products, she plans to hire more people.

Finley’s success didn’t come easily though. The road that got her on this current path could have had a more tragic turn. Finley had been a successful executive until she came down with a rare condition called ankylosing spondylitis. She was an invalid, unable to leave her house for 15 years. The pharmaceutical medicines she was taking cost upwards of $6,000 a month.   With nothing left to lose, she tried medical marijuana. “It gave me back my life,” said Finley.

She embarked on a journey to research the plant, grow it herself and develop her own CBD extracts. “People told me back then there was no market for this since the black market was so strong,” she said, “But everything I have done has been legal.” The word got out and a doctor began sending her stage 4 brain cancer patients, who also had exhausted their traditional treatments and had nothing left to lose. When they went into remission, more and more patients began flocking to her. So far, out of this group she has had 97% go into remission. The demand grew to the point that she could no longer grow her own cannabis. Her products are only for medicinal clients (at this time) and specifically uses a ratio with CBD and THC.

Her company grew too. She was offered $12 million for her company back in June of 2013 when the company’s annual revenue was only $300,000. “I seriously thought about it,” she said. She was even approached to go public but has chosen to hold onto her company. Then she found an investor she trusted called Slow Ventures. She just closed a Series B financing round and said she is set for equity now. “Silicon Valley wants my patents. Blackrock valued them at $12 million at one time and the company at $34 million,” said Finley. “Most everyone though assumes that we’re past a $50 million valuation by now.”

While it sounds like a Cinderella story, it wasn’t. Finley said she didn’t pay herself a salary for seven years. She sold her BMW coupe, her Steinway baby grand piano and even took money out against her house. She didn’t endure all that sacrifice just to quickly give up control of her company or give away her patents. “You have to fight for autonomy,” said Finley, “As a woman, you have to fight ten times as hard to keep your autonomy and get your work recognized, even in this emerging field.” She added with a chuckle, “And try being 65, right? And people walk in and say ‘no, no,no’, this 110-pound woman did not write these patents. Where’s your Ph.D. in Chemistry?”

Now Constance Therapeutics is in FDA approved research through Tetra BioPharma (TBPMF). “I’m really proud I got us to this level of research,” she said. She is also looking for ways to steer consumers towards good products. She’s working with the American Herbal  Products Association and working with Congress. “There are lots of “me too” CBD products that are swamping the market. “People like me have serious work with real evidence,” said Finley, “It’s insulting the people would go on the internet and buy this stuff. It’s often toxic. It’s not an evidence-based product.”

As a female executive, Finley is happy to be part of a shift in the perception of cannabis, especially among women. “Women traditionally haven’t been users of psychoactive drugs like men. There’s a sort of right of passage that men tend to have that women do not. Women also tend to have discomfort with any feeling of being out of control.” Finley is now focusing some of her research on helping with symptoms surrounding menstruation.

Finley says she has a hard time even looking back at the time of her illness, but the result has been life-changing. She can now help improve other people’s health. She travels the world speaking about her research and the product that saved not only her life, but is saving others as well.

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